The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
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The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule. The Notch1 receptor was proposed to be monoubiquitinated before its gamma-secretase cleavage; the targeted lysine has be...
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Overview Regulation of the rate of protein synthesis is of central importance in growth control. Treatment of quiescent cells with growth factors or hormones induces re-entry of cells into the cell cycle, accompanied by an increase in the synthesis of RNA and protein, and culminating in a doubling of protein mass before DNA synthesis and cell division [l]. At the basis of these controlling even...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2010
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000545